The embassy was placed on lockdown following the horrific killing of Russian ambassador, Andrei Karlov, was shot dead in the city.
The man fired at least one shot in the air, reports have claimed, but was apprehended by authorities shortly after.
Staff have now been given permission to leave the compound following the "security incident"
The US State Department for Travel earlier advised all US citizens in the area to steer clear from the embassy while the "ongoing security incident" was fully dealt with.
The embassy is approximately 2.5 miles from where Mr Karlov, on an official visit to Turkey as a representative for Russia, was brutally assassinated.
He suffered five shots to the back from a gunman who shouted "Allahu Akbar" as he carried out the murder.
The killer has been identified as Mevlüt Mert Altintaş, a Turkish police officer aged 22.
Altinaş was killed at the scene.
It is unclear as to whether the two incidents are linked, but the State Department warned US citizens they “should avoid travel to southeast Turkey and carefully consider the risks of travel to and throughout the country”.